Darolutamide (ODM-201)

InformationDarolutamide (ODM-201) Darolutamide (ODM-201, BAY-1841788) is a novel androgen receptor (AR) antagonist that blocks AR nuclear translocation with K i of 11 nM. Phase 3.In vitroIn AR-HEK293 cells stably expressing full-length hAR, ODM-201 inhibits human AR (hAR) with IC50 of 26 nM. ODM-201 inhibits VCaP cell proliferation with IC50 of 230 nM, while has no effect on the viability of AR-negative cell lines tested, DU-145 prostate cancer cells and H1581 lung cancer cells.In vivoIn mice bearing VCaP xenografts, ODM-201 (50/u2009mg/kg, p.o.) significantly inhibits castration-resistant prostate tumor growth.Cell Datacell lines：Concentrations：~10 μMIncubation Time：4 daysPowder Purity:≥99%. Specification: 10mM in DMSO Molecular Formula: C19H19ClN6O2 Molecular Weight: 398.85

UPC:

51183703

Condition:

New

Weight:

0.85 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

D408674-1ml

CAS:

1297538-32-9

Product Size:

1ml