Demethylcantharidate disodium

Demethylcantharidate disodium, an endogenous metabolite , induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer.In VitroDemethylcantharidate (0-100 μM; 0, 12, 24, 48 or 72 hours) disodium inhibits HCC cell proliferation. Demethylcantharidate (0, 9, 18 or 36 µM; 24 hours) disodium dose dependently increases the levels of cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HCC cell lines (SMMC-7721 and Bel-7402) Concentration: 0-100 μM Incubation Time: 0, 12, 24, 48 or 72 hours Result: Showed anti-proliferative activity in the two HCC cell lines. Cell Viability AssayCell Line: HCC cells Concentration: 0, 9, 18 or 36 µM Incubation Time: 24 hours Result: Induced apoptosis in HCC cells via the intrinsic pathway.In VivoDemethylcantharidate disodium significantly decreases hepatocellular carcinoma tumorigenesis of SMMC-7721 cells in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:Solid. Specification: ≥98.0% Molecular Formula: C8H8Na2O5 Molecular Weight: 230.13 PubChem CID: 162368041 Isomeric SMILES: C1CC2C(C(C1O2)C(=O)O)C(=O)O.[Na+].[Na+]

UPC:

51203002

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

D647055-10mg

CAS:

129-67-9

Product Size:

10mg