diABZI-C2-NH2 (C007B-348702)
diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist.In VitroThe author developed a linking strategy to synergize the effect of two symmetry-related amidobenzimidazole (ABZI)-based compounds to create linked
Description
diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist.In VitroThe author developed a linking strategy to synergize the effect of two symmetry-related amidobenzimidazole (ABZI)-based compounds to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function. Intravenous administration of a diABZI STING agonist to immunocompetent mice with established syngeneic colon tumours elicited strong anti-tumour activity, with complete and lasting regression of tumors. diABZI-C2-NH2 is covalently immobilized on sepharose beads and is used to affinity-capture potential target proteins from a THP1 cell lysate. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:Solid. Specification: 0.96 Molecular Formula: C36H43N13O4 Molecular Weight: 721.81
Specifications
- UPC:
- 51311810
- Condition:
- New
- Weight:
- 1.06 Ounces
- HazmatClass:
- No;ManufacturerName=Aladdin Scientific"
- Quantity:
- 1
- Unit of Measurement:
- EA
- WeightUOM:
- LB
- MPN:
- D649967-5mg
- CAS:
- 2137975-93-8
- Product Size:
- 5mg
- Controlled Substances and Cyanide:
- Yes
Catalog No.
C007B-348702
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