DIQUAFOSOL TETRASODIUM (C005B-309628)

Biochem/physiol Actions

Diquafosol (Up4U, INS365) is a selective purinergic receptor P2Y2 agonist (EC50 = 100 nM/P2Y2, 400 nM/P2Y4, 20 μM/P2Y6, >100 μM/P2Y1 by calcium mobilization using respective 1321N P2Y subtype transfectants). In addition to its in vivo efficacy in anmial dry eye models, diquafosol is also shown to enhance mucociliary clearance in sheep and stimulate vaginal moisture in ovariectomized rabbits.

P2Y₂/P2Y₄ purinoceptor agonist: EC₅₀ = 0.10 μM at P2Y₂, 0.4 μM at P2Y₄ (20 μM at P2Y₆) in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y_1, P2Y_2, P2Y₄ and P2Y₆

Diagnostic Implications

In clinical development for the treatment of dry eye and chronic lung disease, such as cystic fibrosis

UPC:

51182405

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

5

Unit of Measurement:

MG

MPN:

SML3058-5MG

CAS:

211427-08-6