DMT-2''-F-DA(BZ) AMIDITE SEPTUM (C005B-238807)

General description

DMT-2′Fluoro-dA(bz) Phosphoramidite is a 2′Fluoro phosphoramidite used to synthesize oligonucleotides that are more thermally stable and provide increased nuclease resistance.Its key features are-

• Can be employed together with DNA or RNA phosphoramidites
• Recommended deprotection conditions are 8 hours at 55 °C using concentrated ammonia solution, or with AMA for 10 minutes at 65 °C
• Synthesis of 2′Fluoro oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 3 minutes compared to 90 seconds for DNA monomers)
• Consistent lot-to-lot high purity and performance
• Manufactured under a certified ISO 9001 quality system

Application

DMT-2′Fluoro-dA(bz) Phosphoramidite is suitable for use in the synthesis of 2′-fluoro modified oligonucleotide sequences by employing automated solid-phase chemistry.

Legal Information

OligoPilot is a registered trademark of Cytiva

„KTA is a registered trademark of Cytiva

Molecular Weight: 875.92. Empirical Formula: C₄₇H₅₁FN₇O₇P. biological source: non-animal source (no BSE/TSE risk). Quality Level: 200. product line: Proligo Reagents. Assay: ≥. 99% (³¹P-NMR), ≥. 99.0% (reversed phase HPLC). form: powder. technique(s): oligo synthesis: suitable. impurities: ≤. 0.3% water content (Karl Fischer), ≤. 0.5% P(III) Impurities 100-169ppm (³¹P-NMR), ≤. 0.5% single Impurity (reversed phase HPLC), ≤. 3% residual Solvent content. color: white to off-white. »: conforms (UV/VIS Identity). suitability: conforms to structure for H-NMR, conforms to structure for LC-MS. compatibility: configured for („KTA^®. and OligoPilot^®. ). nucleoside profile: base: deoxyadenosine
base protecting group: benzoyl
2' protecting group: fluoro
5' protecting group: DMT
deprotection: fast/standard. storage temp.: −. 20°C. SMILES string: CC(C)N(C(C)C)P(OCCC#N)O[C@H]([C@H](O1)COC(C2: CC: C(OC)C: C2)(C3: CC: C(OC)C: C3)C4: CC: CC: C4)[C@@H](F)[C@@H]1N5C6: NC: NC(NC(C7: CC: CC: C7): O): C6N: C5. InChI: 1S/C47H51FN7O7P/c1-31(2)55(32(3)4)63(60-27-13-26-49)62-42-39(61-46(40(42)48)54-30-52-41-43(50-29-51-44(41)54)53-45(56)33-14-9-7-10-15-33)28-59-47(34-16-11-8-12-17-34,35-18-22-37(57-5)23-19-35)36-20-24-38(58-6)25-21-36/h7-12,14-25,29-32,39-40,42,46H,13,27-28H2,1-6H3,(H,50,51,53,56)/t39-,40-,42-,46-,63?/m1/s1. InChI key: VCCMVPDSLHFCBB-MSIRFHFKSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

UPC:

51332849

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

GR

MPN:

A211250-1G

Controlled Substances and Cyanide:

Yes