DPBQ

DPBQ activates p53 and triggers apoptosis in a polyploid-specific manner, but does not inhibit topoisomerase or bind DNA. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cellsIn VitroDPBQ elicits apoptosis and cell death and is selective for effects in 4N cells. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells. Knockdown of TP53 restores proliferation of tetraploid cells in the presence of DPBQ. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:p53. Specification: ≥98.0% Molecular Formula: C24H14N2O2 Molecular Weight: 362.38 PubChem CID: 364074 Isomeric SMILES: C1=CC=C(C=C1)C2=C(N=C3C(=N2)C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5

UPC:

51111657

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

D646517-5mg

CAS:

7029-89-2

Product Size:

5mg