DRF-1042 (C007B-348625)

DRF-1042 is an orally active derivative of Camptothecin. DRF-1042 acts to inhibit DNA topoisomerase I . DRF-1042 shows good anticancer activity against a panel of human cancer cell lines including multi-agent resistance (MDR) phenotypeIn VitroDRF-1042 demonstrates superior lactone stability and good in vitro anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoIn clonogenic assay against murine, canine and human bone marrow cells, DRF-1042 treatment shows less mylosupression that supports the possibility of protracted dose schedule in both experimental and clinical studies. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:DNA topoisomerase I. Specification: 0.98 Molecular Formula: C22H20N2O6 Molecular Weight: 408.4 PubChem CID: 23631031 Isomeric SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3C(C4=CC5=CC=CC=C5N=C4C3=C2)OCCO)O

UPC:

51111633

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

D649596-10mg

CAS:

200619-13-2

Product Size:

10mg