Dronedarone HCl

InformationDronedarone HCl Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel , sodium channel and calcium channel , used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).In vitroDronedarone reduces the incidence of early and delayed after depolarizations evoked by 1 mM Dofetilide and 0.2 mM Strophantidine in Purkinje fibres. Dronedarone (10 mM) markedly reduces the L-type calcium current (76.5%) and the rapid component of the delayed rectifier potassium current (97%) in ventricular myocytes. Dronedarone inhibits the activity of I(K(ACh)) channels recorded from cell-attached patches by reducing the channel open probability (from 0.56 to 0.11) without modification of the single-channel conductance in single cells isolated from sinoatrial node (SAN) tissue of rabbit hearts. Dronedarone exhibits a state-dependent inhibition of the fast Na(+) channel current with an IC50 of 0.7 μM in guinea pig ventricular myocytes, when the holding potential (V (hold)) is -80 mV. Dronedarone blocks Ca(2+) currents elicited by rectangular pulses at V (hold)/u2009=/u2009-40 mV with IC50 value of 0.4 μM, whereas at V (hold)/u2009=/u2009-80 mV, Dronedarone (10 μM) blocks only 20/u2009% of the current.In vivoDronedarone increases action potential duration in normal hearts of rats. Dronedarone reduces the late sustained K(+) current, I(K) (or Isus) by 69%. Dronedarone induces only a tonic block of I(K). Dronedarone induces a weak increase in the fast transient outward current, I(to), in rats after myocardial infarction.Cell Datacell lines：Human breast cancer cells MDA-MB-468Concentrations：Incubation Time：Powder Purity:≥99%. Specification: 10mM in DMSO Molecular Formula: C31H44N2O5S·HCl Molecular Weight: 593.22

UPC:

51361938

Condition:

New

Weight:

0.85 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

D408521-1ml

CAS:

141625-93-6

Product Size:

1ml