Information(E/Z)-BCI (E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.TargetsROS ; DUSP1 (Cell-free assay); DUSP6 (Cell-free assay) ; 8.0 μM(EC50); 13.3 μM(EC50)
Specifictaions: ≥98%
MDL Number: C22H23NO
Molecular Formula: 317.42
PubChem CID: 5475586
Isomeric SMILES: C1CCC(CC1)NC\2C3=CC=CC=C3C(=O)/C2=C\C4=CC=CC=C4
Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/Z412154-SCI_9c2f67ecb423771123e5f9a26c8d78a0.pdf
- UPC:
- 42182319
- Condition:
- New
- Availability:
- 4-8 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- Z412154-1mg
- CAS:
- 15982-84-0
- Product Size:
- 1mg
- Hazard Statement Codes:
- H400
- Precautionary Statement Codes:
- P391;P501;P273
