EN460 (C008B-271271)

EN460 is a selective endoplasmic reticulum oxidation 1 (ERO1) inhibitor. EN460 ( IC 50 of 1.9 μM) interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation.In VitroExposure of cells to EN460 or QM295 resulted in the accumulation of an ERO1α form with lower mobility, indicative of the reduced state. EN460 and QM295 were also found to activate an unfolded protein response reporter in cultured 293T cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:Solid

Specifications & Purity: EN460 is a selective endoplasmic reticulum oxidation 1 (ERO1) inhibitor. EN460 ( IC 50 of 1.9 μM) interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation.In VitroExposure of cells to EN460 or QM295 resulted in the accumulation of an ERO1α form with lower mobility, indicative of the reduced state. EN460 and QM295 were also found to activate an unfolded protein response reporter in cultured 293T cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:Solid

Grade: Moligand™

Molecular Formula: C22H12ClF3N2O4

Molecular Weight: 460.79

PubChem CID: 1016023

Isomeric SMILES: C1=CC=C(C=C1)C2=CC=C(O2)/C=C\3/C(=NN(C3=O)C4=CC(=C(C=C4)Cl)C(=O)O)C(F)(F)F

Storage Temperature: Store at -20°C

Shipped in: Ice chest + Ice pads

UPC:

51442432

Weight:

1.06 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

E648133-25mg

Country of Origin:

China

CAS:

496807-64-8

Product Size:

25mg

Harmonized Tariff Code:

2931.90.90