General description
An excellent derivative for minimizing aspartimide formation during Fmoc SPPS of Asp-containing peptides [1]. The bulky OMpe protecting group offers considerably more protection against the formation of aspartimide-related by-products than the commonly used OtBu group [1,2].
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Literature references
[1] A. Karlström (1996) Tetrahedron Lett., 37, 4243.
[2] M. Mergler (2003) J. Pept. Sci., 9, 518.
Linkage
Replaces: 04-12-1259
Analysis Note
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (DC (018A)): ≥ 98 %
Enantiomeric purity: ≥ 99.5 % (a/a)
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
To see the solvent systems used for TLC of Novabiochem® products please click here.
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 41115717
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 8521040001