FMOC-ASP(OMPE)-OH 5 G

General description

An excellent derivative for minimizing aspartimide formation during Fmoc SPPS of Asp-containing peptides ^[1]. The bulky OMpe protecting group offers considerably more protection against the formation of aspartimide-related by-products than the commonly used OtBu group ^[1,2].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] A. Karlström (1996) Tetrahedron Lett., 37, 4243.
^[2] M. Mergler (2003) J. Pept. Sci., 9, 518.

Linkage

Replaces: 04-12-1259

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (DC (018A)): ≥ 98 %
Enantiomeric purity: ≥ 99.5 % (a/a)
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:

13111000

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

5

Unit of Measurement:

GR

MPN:

8521040005

CAS:

180675-08-5