FN-1501 (C008B-265831)

FN-1501 is a potent inhibitor of FLT3 and CDK , with IC 50 s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3 , respectively. FN-1501 has anticancer activity.In VitroFN-1501 is a potent inhibitor of FLT3 and CDK, with IC 50 s of 2.47 ± 0.21, 0.85 ± 0.28, 1.96 ± 0.08 and 0.28 ± 0.01 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 shows potent inhibitory activity against several tumor cells, such as MGC803, RS4 11, MCF-7, HCT-116, and NCI-H82, with GI 50 s of 0.37 ± 0.04, 0.05 ± 0.01, 2.84 ± 0.25, 0.09 ± 0.04, 0.11 ± 0.02 nM, respectively. In VivoFN-1501 exhibits potent antitumor activity, and shows little cytotoxicity on normal lymphocyte cells, with LD 50 of 185.67 mg/kg in ICR mice. FN-1501 (15. 30, or 40 mg/kg/d, i.v.) dose-dependently and significantly suppresses the growth of tumor in MV4-11-cell-inoculated-xenograft mice . Form:SolidIC50& Target:Cdk4/cyclin D1 0.85 nM (IC 50 ) CDK6/cyclinD1 1.96 nM (IC 50 ) cdk2/cyclin A 2.47 nM (IC 50 ) FLT3 0.28 nM (IC 50 )

Specifications & Purity: FN-1501 is a potent inhibitor of FLT3 and CDK , with IC 50 s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3 , respectively. FN-1501 has anticancer activity.In VitroFN-1501 is a potent inhibitor of FLT3 and CDK, with IC 50 s of 2.47 ± 0.21, 0.85 ± 0.28, 1.96 ± 0.08 and 0.28 ± 0.01 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 shows potent inhibitory activity against several tumor cells, such as MGC803, RS4 11, MCF-7, HCT-116, and NCI-H82, with GI 50 s of 0.37 ± 0.04, 0.05 ± 0.01, 2.84 ± 0.25, 0.09 ± 0.04, 0.11 ± 0.02 nM, respectively. In VivoFN-1501 exhibits potent antitumor activity, and shows little cytotoxicity on normal lymphocyte cells, with LD 50 of 185.67 mg/kg in ICR mice. FN-1501 (15. 30, or 40 mg/kg/d, i.v.) dose-dependently and significantly suppresses the growth of tumor in MV4-11-cell-inoculated-xenograft mice . Form:SolidIC50& Target:Cdk4/cyclin D1 0.85 nM (IC 50 ) CDK6/cyclinD1 1.96 nM (IC 50 ) cdk2/cyclin A 2.47 nM (IC 50 ) FLT3 0.28 nM (IC 50 )

Grade: Moligand™

Molecular Formula: C22H25N9O

Molecular Weight: 431.49

PubChem CID: 72195175

Isomeric SMILES: CN1CCN(CC1)CC2=CC=C(C=C2)NC(=O)C3=C(C=NN3)NC4=NC=NC5=C4C=CN5

Storage Temperature: Protected from light;Store at -20°C

Shipped in: Ice chest + Ice pads

UPC:

51473101

Weight:

1.09 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

F650483-25mg

Country of Origin:

China

CAS:

1429515-59-2

Product Size:

25mg

Harmonized Tariff Code:

2931.90.90