G-5555 hydrochloride (C007B-358220)

G-5555 hydrochloride is a potent and selective p21-activated kinase 1 ( PAK1 ) inhibitor with a K i of 3.7 nM.Appearance:SolidIn Vitro:G-5555 shows excellent kinase selectivity and inhibits only eight out of the 235 kinases tested other than PAK1 with inhibition >70%: PAK2, PAK3, KHS1, Lck, MST3, MST4, SIK2, and YSK1. The IC 50 s of G-5555 against SIK2, PAK2, KHS1, MST4, YSK1, MST3 and LIn Vivo:G-5555 exhibits low blood clearance and an acceptable half-life. Good oral exposure (AUC=30 μM•h) and high oral bioavailability (F=80%) are achieved. In an H292 non-small cell lunger cancer (NSCLC) xenograft study in mice, G-5555 inhibits phosphorylaBiological Activity:G-5555 hydrochloride is a potent and selective p21-activated kinase 1 ( PAK1 ) inhibitor with a K i of 3.7 nM. Specification: 0.98 Molecular Formula: C25H26Cl2N6O3 Molecular Weight: 529.42

UPC:

51161726

Condition:

New

Weight:

1.09 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

G658780-5mg

Product Size:

5mg