Gardiquimod (C007B-171884)

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.Biochem/physiol ActionsGardiquimod is a potent and specific agonist for human or mouse Toll-like receptor 7 (TLR7). Also, at high concentration gardiquimod activates TLR8. Similarly to imiquimod, gardiquimod could mimic the effects of viral nucleic acids on the immune system.Gardiquimod is developed as a new imidazoquinoline compound. It stimulates NF-κB (nuclear factor-κB) activation in cells expressing human or murine toll like receptor 7 (TLR7). Gardiquimod is found to be ten times more efficient than imiquimod. It induces splenocyte activation and prevents murine B16 melanoma growth and metastasis. Gardiquimod might serve as a therapeutic agent to prevent HIV-1 (human immunodeficiency virus - 1) transmission. It hinders the life cycle of HIV-1, by blocking the action of HIV-1 reverse transcriptase. Specification: 0.97 Molecular Formula: C17H23N5O Molecular Weight: 313.4 PubChem CID: 44592366 Isomeric SMILES: CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/G274801-SCI_bc9a61aa326caa87809c785fc5326c13.pdf

UPC:

51201517

Condition:

New

Weight:

0.96 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

G274801-25mg

CAS:

1020412-43-4

Product Size:

25mg

Hazard Statement Codes:

H315:H319:H335

Precautionary Statement Codes:

P261:P264:P271:P280:P302+P352:P304+P340:P305+P351+P338:P362+P364:P405:P403+P233:P501