GPR120 Agonist 3 (C007B-357976)

GPR120 Agonist 3 is a selective Gpr120 agonist with a logEC 50 of −7.62.In VitroGPR120 Agonist 3 is fully selective for Gpr120 (logEC50=−7.62) with negligible activity towards Gpr40. GPR120 Agonist 3 produces concentration dependent increases in IP 3 production from both human and mouse Gpr120 expressing cells. GPR120 Agonist 3 leads to a concentration-dependent response to recruit β-arrestin-2 in both human and mouse Gpr120 expressing cells, with EC 50 s of ~0.35 μM. GPR120 Agonist 3 strongly and comparably inhibits LPS-induced phosphorylation of Tak1, Ikkβ, and Jnk and blocked IκB degradation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoGPR120 Agonist 3 causes improved insulin sensitivity with increased glucose infusion rates, enhanced insulin stimulated-glucose disposal rate, along with a marked increase in the ability of insulin to suppress hepatic glucose production only in WT mice. GPR120 Agonist 3 treatment has beneficial effects on hepatic lipid metabolism, causing decreased hepatic steatosis, decreased liver triglycerides, and DAGs, along with reduced saturated free fatty acid conten . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:logEC50: −7.62. Specification: 0.99 Molecular Formula: C19H23ClF3NO3 Molecular Weight: 405.84 PubChem CID: 73777063 Isomeric SMILES: C1CC2(CCC1CC(=O)O)CCN(CC2)C3=C(C=CC(=C3)OC(F)(F)F)Cl

UPC:

51183610

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

G651533-2mg

CAS:

1599477-75-4

Product Size:

2mg