GSK180736A (GSK180736) (C007B-173533)

InformationGSK180736A (GSK180736) GSK180736A (GSK180736), developed as a Rho-associated, coiled-coil-containing protein kinase inhibitor, binds to GRK2(G protein-coupled receptor kinase 2) with logIC50 pf -6.6 (logIC50 -4.0 for GRK5 and >-3 for GRK1); ≥400-fold selective for GRK2 over both GRK1 and GRK5.TargetsROCK (Cell-free assay); GRK2 (Cell-free assay) 100 nM; 6.6(pIC50)In vitroGSK180736A exhibits a 770 nM IC50 value against GRK2 and 300-fold less potency against GRK5. It is a weak inhibitor of PKA with an IC50 of 30 μM, but highly potent against ROCK1 (IC50 = 100 nM). Specification: 0.98 Molecular Formula: C19H16FN5O2 Molecular Weight: 365.36 PubChem CID: 11233873 Isomeric SMILES: CC1=C(C(NC(=O)N1)C2=CC=C(C=C2)F)C(=O)NC3=CC4=C(C=C3)NN=C4 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/G414025-SCI_1a5daa61694c8ae5689f03602a74b47f.pdf

UPC:

51182701

Condition:

New

Weight:

0.96 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

G414025-25mg

CAS:

817194-38-0

Product Size:

25mg

Hazard Statement Codes:

H302:H315:H319:H335

Precautionary Statement Codes:

P261:P305+P351+P338