GSK2879552 2HCl (C007B-173496)

InformationGSK2879552 2HCl GSK2879552 2HCl is a potent, selective, orally bioavailable, irreversible LSD1 inhibitor with K i app of 1.7 μM. Phase 1.TargetsLSD1 (Cell-free assay) 1.7 μM(Ki)In vitroIn 165 cell lines, GSK2879552 inhibits the growth of 9/28 small cell lung carcinoma (SCLC) lines and 20/29 AML lines ranged from 40% to 100%. The subset of SCLC lines and primary samples that undergo growth inhibition in response to GSK2879552 exhibit DNA hypomethylation of a signature set of probes.In vivoIn SCLC xenograft bearing mice, GSK2879552 (1.5 mg/kg, p.o.) demonstrates tumor growth inhibition by 17%-83%.Cell Research(from reference)Cell lines：165 human cancer cell lines Concentrations：~10 μM Incubation Time：6 d. Specification: 0.98 Molecular Formula: C23H28N2O2.2HCl Molecular Weight: 437.4 PubChem CID: 156588618 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/G413833-SCI_97e253fbf28a2007987a26dc572a4b7a.pdf

UPC:

51112000

Condition:

New

Weight:

0.96 Ounces

HazmatClass:

No;ManufacturerName=Aladdin Scientific"

WeightUOM:

LB

MPN:

G413833-25mg

CAS:

1902123-72-1

Product Size:

25mg

Hazard Statement Codes:

H302:H315:H319:H335

Precautionary Statement Codes:

P261:P264:P270:P271:P280:P330:P362:P301+P312:P302+P352:P304+P340:P305+P351+P338:P332+P313:P337+P313:P405:P403+P233:P501

Controlled Substances and Cyanide:

Yes