GSK2981278 (C007B-173433)

InformationGSK2981278 GSK2981278 is a highly potent and selective inverse agonist for RORγ .TargetsRORγIn vitroGSK2981278 has no significant effect on RORα-dependent activation. GSK2981278 significantly inhibits production of the Th17 signature (IL-17A, IL-17F, IL-22 and IL-23) in multiple in vitro and human tissue-based assays.In vivoGSK2981278 attenuates inflammation in a mouse model of psoriasis. Topical treatment with GSK2981278 will significantly limit Th17-type cytokine expression and should therefore lead to improved clinical outcomes for patients. Specification: 0.98 Molecular Formula: C25H35NO5S Molecular Weight: 461.61 PubChem CID: 89875987 Isomeric SMILES: CCC1=CC=C(C=C1)N(CC(C)C)S(=O)(=O)C2=CC(=C(C=C2)OCC3CCOCC3)CO Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/G413546-SCI_e3c646050bf39d19a44f9f12bba8b924.pdf

UPC:

41116127

Condition:

New

Weight:

0.96 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

G413546-5mg

CAS:

1474110-21-8

Product Size:

5mg

Hazard Statement Codes:

H302:H315:H319:H335

Precautionary Statement Codes:

P261:P280:P301+P312:P302+P352:P305+P351+P338