GSK3-IN-3

GSK3-IN-3 is a mitophagy inducer, inducing Parkin-dependent mitophagy . GSK3-IN-3 is also a GSK-3 inhibitor with an IC 50 value of 3.01 μM. GSK3-IN-3 is non-ATP nor substrate competitive and is neuroprotective against 6-OHDAIn VitroGSK3-IN-3 (VP07) (25 μM; 24 h) induces mitophagy in Parkin-expressing U2OS-iMLS cells with restricted potency. GSK3-IN-3 (1.56-25 μM; 24 h) results in mitochondria fission with mitochondrial morphology change in U2OS-iMLS-Parkin cells. GSK3-IN-3 (VP0.7) (5 μM, 10 μM; ) shows neuroprotection against 6-OHDA albeit in a Parkinson's disease in vitro cellular model in SH-SY5Y cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. ImmunofluorescenceCell Line: Parkin-expressing U2OS-iMLS cells Concentration: 1.56 μM, 3.12 μM, 6.25 μM, 12.5 μM, and 25 μM; Incubation Time: 24 hours Result: Induced a mitochondrial morphology change from a filament-shaped network to a more round-shaped network. Cell Viability AssayCell Line: SH-SY5Y cells Concentration: 0.5 μM, 1 μM, 3 μM, 5 μM, and 10 μM Incubation Time: 16 hours; with 35 μM 6-OHDA Result: Inhibited cell growth with an IC 50 value of 2.57 μM.Form:SolidIC50& Target:IC50: 3.01 μM (GSK-3)

Specifications & Purity: GSK3-IN-3 is a mitophagy inducer, inducing Parkin-dependent mitophagy . GSK3-IN-3 is also a GSK-3 inhibitor with an IC 50 value of 3.01 μM. GSK3-IN-3 is non-ATP nor substrate competitive and is neuroprotective against 6-OHDAIn VitroGSK3-IN-3 (VP07) (25 μM; 24 h) induces mitophagy in Parkin-expressing U2OS-iMLS cells with restricted potency. GSK3-IN-3 (1.56-25 μM; 24 h) results in mitochondria fission with mitochondrial morphology change in U2OS-iMLS-Parkin cells. GSK3-IN-3 (VP0.7) (5 μM, 10 μM; ) shows neuroprotection against 6-OHDA albeit in a Parkinson's disease in vitro cellular model in SH-SY5Y cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. ImmunofluorescenceCell Line: Parkin-expressing U2OS-iMLS cells Concentration: 1.56 μM, 3.12 μM, 6.25 μM, 12.5 μM, and 25 μM; Incubation Time: 24 hours Result: Induced a mitochondrial morphology change from a filament-shaped network to a more round-shaped network. Cell Viability AssayCell Line: SH-SY5Y cells Concentration: 0.5 μM, 1 μM, 3 μM, 5 μM, and 10 μM Incubation Time: 16 hours; with 35 μM 6-OHDA Result: Inhibited cell growth with an IC 50 value of 2.57 μM.Form:SolidIC50& Target:IC50: 3.01 μM (GSK-3)

Grade: Moligand™

Molecular Formula: C24H35N3O4

Molecular Weight: 429.55

Storage Temperature: Store at -20°C

Shipped in: Ice chest + Ice pads

UPC:

51373478

Weight:

1.09 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

G650918-1mg

Country of Origin:

China

CAS:

331963-27-0

Product Size:

1mg

Harmonized Tariff Code:

2931.90.90