GSTO-IN-2 (C007B-357077)

GSTO-IN-2 is a glutathione S-transferase inhibitor with IC 50 s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.In VitroGSTO-IN-2 is compound 3 in the reference. GSTO-IN-2 shows synergetic effect with chemotherapy drugs against two breast cancer cell lines through the inactivation of GST isozymes. The maximal enhancement of cisplatin-induced inhibition of cell viability is observed at 50 μM GSTO-IN-2, up to 640% against MCF-7 and up to 270% against MDA-MB-231. Viability inhibition of thiotepa is enhanced by GSTO-IN-2 (25 and 50 μM), up to 170-320% against MCF-7 and up to 180-270% against MDA-MB-231.. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: 3.6 μM (GSTA2), 16.3 μM (GSTM1), 1.4 μM (GSTP1-1). Specification: ≥98.0% Molecular Formula: C33H52N2O9 Molecular Weight: 620.77 PubChem CID: 75090607 Isomeric SMILES: CC(CCC(=O)O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)OC(=O)C(CC(=O)O)NC(=O)CCC(C(=O)O)N)C)C

UPC:

51183109

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

G646501-5mg

CAS:

1202710-57-3

Product Size:

5mg