GW-6604 (C008B-265636)

GW-6604 is an ALK5 inhibitor with an IC 50 value of 140 nM for inhibiting its autophosphorylation, and can be used in the study of liver fibrosis.In VitroGW-6604 (0-10 μM, ) inhibits TGF-β-induced PAI-1 transcription and secretion in HepG2 cells with an IC 50 value of 500 nM, effectively blocking the Smad-dependent response. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoGW-6604(p.o., 25-80 mg/kg, twice a day, 3 weeks) dependently inhibits hepatic COL IA1 overexpression in an acute DMN model in SD rats, reducing its expression by 80%. Normal liver weight was maintained, liver fibrosis was effectively reduced and matrix degeneration was increased . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:Solid

Specifications & Purity: GW-6604 is an ALK5 inhibitor with an IC 50 value of 140 nM for inhibiting its autophosphorylation, and can be used in the study of liver fibrosis.In VitroGW-6604 (0-10 μM, ) inhibits TGF-β-induced PAI-1 transcription and secretion in HepG2 cells with an IC 50 value of 500 nM, effectively blocking the Smad-dependent response. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoGW-6604(p.o., 25-80 mg/kg, twice a day, 3 weeks) dependently inhibits hepatic COL IA1 overexpression in an acute DMN model in SD rats, reducing its expression by 80%. Normal liver weight was maintained, liver fibrosis was effectively reduced and matrix degeneration was increased . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:Solid

Molecular Formula: C19H14N4

Molecular Weight: 298.34

PubChem CID: 9861063

Isomeric SMILES: C1=CC=C(C=C1)C2=NC=CC(=C2)C3=C(NN=C3)C4=CC=CC=N4

Storage Temperature: Protected from light;Store at -20°C

Shipped in: Ice chest + Ice pads

UPC:

41115700

Weight:

1.06 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

G646467-1mg

Country of Origin:

China

CAS:

452342-37-9

Product Size:

1mg

Harmonized Tariff Code:

2931.90.90