HPK1-IN-3 (C007B-360720)

HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC 50 of 0.25 nM. HPK1-IN-3 has IL-2 cellular potency with an EC 50 of 108 nM in human peripheral blood mononuclear cells (PBMCs).Appearance:SolidIC50& Target:HPK1 0.25 nM (IC 50 )In Vitro:HPK1-IN-3 (compound 27; 0.25-4 μM; 24-h) treatment shows a statistically significant elevation of proinflammatory cytokines IL-6 and TNF-α was observed in a concentration-dependent manner in human monocyte-derived dendritic cells. MCE has not indepenBiological Activity:HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC 50 of 0.25 nM. HPK1-IN-3 has IL-2 cellular potency with an EC 50 of 108 nM in human peripheral blood mononuclear cells (PBMCs). Specification: 0.98 Molecular Formula: C23H22F4N6O2 Molecular Weight: 490.45

UPC:

51321502

Condition:

New

Weight:

1.09 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

H658896-25mg

Product Size:

25mg