HUMAN B2M (BETA-2 MICROGLOBULIN) ELISA KIT FOR SERUM PLASMA CELL CULTURE SUPERNATANT AND URINE

General description

β2-microglobulin (B2M) is a non-glycosylated polypeptide composed of 99 amino acids. It is present on the surface of all nucleated cells. The protein is characterized with a single polypeptide chain, which is linked noncovalently to major histocompatibility complex (MHC) class I cell surface antigen. The gene coding for B2M is mapped to human chromosome 15q.

The Human BDNF ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BDNF in serum, plasma, cell culture supernatants and urine.

Immunogen

Recombinant Human β-2-Microglobulin

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

β2-microglobulin (B2M) plays a vital role in cell survival, proliferation and metastasis in various types of cancer. Elevated concentration of β-2-microglobulin (B2M) can be considered as a prognostic marker for hemophagocytic lymphohistiocytosis (HLH). Elevated concentration of circulating B2M, due to renal dysfunction and long term hemodialysis, leads to dialysis-related amyloidosis. Overexpression of serum B2M is observed in hepatitis C virus (HCV) related chronic liver diseases, therefore it might act as a potential marker for the HCV disease progression towards cirrhosis and carcinoma. Missense mutation in the B2M gene results in familial hypercatabolic hypoproteinemia (FHH).

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

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UPC:

41181549

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

KT

MPN:

RAB0024-1KT

Temperature Control Device:

Yes