ICCB-19 HYDROCHLORIDE (C005B-309728)

Catalog No.: C005B-309728
Mfr. No.: SML3006-25MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 25
UOM: MG

Price: $632.43

List Price: $702.70

Biochem/physiol Actions ICCB-19 is a cell penetrant apoptosis inhibitor that activates autophagy leading to restoration of cellular homeostasis in cells with accumulated mutant tau, α:-synuclein, or huntingtin. ICCB-19 potently and selectively

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Description
Specifications

Biochem/physiol Actions

ICCB-19 is a cell penetrant apoptosis inhibitor that activates autophagy leading to restoration of cellular homeostasis in cells with accumulated mutant tau, α-synuclein, or huntingtin. ICCB-19 potently and selectively inhibits TRADD. It binds to the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apparently ICCB-19 releases cIAP1/2 or TRAF2 from TRADD thus promoting the K63-linked ubiquitination of beclin 1.

UPC:: 51172425
Condition:: New
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3006-25MG
CAS:: 1803605-68-6
Controlled Substances and Cyanide:: Yes

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