IDH889 (C007B-362425)

IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1) . IDH889 has potent selectivity for IDH1 R132* mutations, with IC 50 s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1 R132H , IDH1 R132C and IDH1 wt , respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC 50 of 0.014 μMForm:SolidIC50& Target:IC50: 0.02 μM (IDH1 R132H ), 0.072 μM (IDH1 R132C ), 1.38 μM (IDH1 wt ). Specification: 0.98 Molecular Formula: C23H25FN6O2 Molecular Weight: 436.48 PubChem CID: 71542286 Isomeric SMILES: CC1=C(C=CC(=C1)C2=CN=C(N=C2)[C@H](C)NC3=NC=CC(=N3)N4[C@H](COC4=O)C(C)C)F

UPC:

51171524

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

I650995-1mg

CAS:

1429179-07-6

Product Size:

1mg