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Sigma-Aldrich

ILOPERIDONE (C005B-311981)

Biochem/physiol Actions Iloperidone is an atypical antipsychotic, a combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Iloperidone targets a selective set of dopamine, serotonin and also norepinephrine receptor subtypes.

Description

Biochem/physiol Actions

Iloperidone is an atypical antipsychotic, a combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Iloperidone targets a selective set of dopamine, serotonin and also norepinephrine receptor subtypes. Like similar atypical antipsychotics, Iloperidone has higher affinity for the 5-HT2A receptor (Ki < 10 nM) than for the D2 receptor (Ki = 10€“100) nM). Iloperidone has high affinity for dopamine D3 (Ki < 10 nM) and lower affinity for other serotonin or dopamine subtypes. Unlike most atypical antipsychotics, Iloperidone also has high affinity for norepinephrine alpha1 receptors (Ki < 10 nM) which may contribute to the drug€²s efficacy on mood and cognition.

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Specifications
UPC:
51332001
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
Yes
Quantity:
50
Unit of Measurement:
MG
MPN:
SML1528-50MG
CAS:
133454-47-4
Catalog No. C005B-311981
Price: $572.69
List Price: $636.32
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