INTERFERON-?-IFN?-R INTERACT 1PC X 25MG (C005B-227762)

General description

A nonpeptidic thiophenylmethanamine compound that binds interferon-α (K_d = 4 µM for human IFN-α) and prevents IFN-α and IFNAR interaction-dependent IFN-α production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA (vaccinia virus Ankara) infection (IC₅₀<4.5 µM), TLR9 ligand CpG2216 stimulation, VSV-M2 (vesicular stomatitis virus variant 2) infection, or MDA5/TLR3 ligand poly(I:C) stimulation (by >95% inhibition at 9 µM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (≤4.5 µM).

A nonpeptidic thiophenylmethanamine compound that binds interferon-α (K_d = 4 µM for human IFN-α) and prevents IFN-α and IFNAR interaction-dependent IFN-α production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA infection (IC₅₀<4.5 µM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (≤4.5 µM).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Geppert, T., et al. 2011. Angew. Chem. Int. Ed.51, 258.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 279.40 (free base basis). Empirical Formula: C₁₈H₁₇NS · xHCl. Quality Level: 100. Assay: ≥. 98% (HPLC). form: solid. manufacturer/tradename: Calbiochem^®. . storage condition: OK to freeze, desiccated (hygroscopic), protect from light. color: white. solubility: DMSO: 50 . mg/mL, clear, colorless. shipped in: ambient. storage temp.: −. 20°C. SMILES string: CNCC1: CC: CC: C1SC2: CC: CC3: C2C: CC: C3.[xHCl]. Storage Class Code: 11 - Combustible Solids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

Shipping Information:

Dry Ice Surcharge & Ice Pack Shipments: $40

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UPC:

51342709

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

25

Unit of Measurement:

MG

MPN:

407325-25MG

Temperature Control Device:

Yes