Interleukin-6; Murine IL-6, 1mg

IL-6, Interleukin-6, murine (mouse): Murine Interleukin-6 Interleukin 6 is a multi-functional protein that plays important roles in host defense, acute phase reactions, immune responses, and hematopoiesis. IL-6 is expressed by a variety of normal and transformed cells including T cells, B cells, monocytes/macrophages, fibroblasts, hepatocytes, keratinocytes, astrocytes, vascular endothelial cells, and various tumor cells. The production of IL-6 is up-regulated by numerous signals including mitogenic or antigenic stimulation, LPS, calcium ionophore, IL-1, IL-2, IFN, TNF, PDGF, and viruses. IL6 expression in monocytes is inhibited by IL-4 and IL-13. Source: Escherichia coli. Molecular Weight: Approximately 21.7 kDa, a single non-glycosylated polypeptide chain containing 187 amino acids. Quantity: 2ug/10ug/1.0 mg AA Sequence: FPTSQVRRGD FTEDTTPNRP VYTTSQVGGL ITHVLWEIVE MRKELCNGNS DCMNNDDALA ENNLKLPEIQ RNDGCYQTGY NQEICLLKIS SGLLEYHSYL EYMKNNLKDN KKDKARVLQR DTETLIHIFN QEVKDLHKIV LPTPISNALL TDKLESQKEW LRTKTIQFIL KSLEEFLKVT LRSTRQT Purity: >97% by SDS-PAGE and HPLC analyses. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is < 0.02 ng/ml, corresponding to a specific activity of > 5 x 107 units/mg. Formulation: Lyophilized from a 0.2mm filtered concentrated solution in PBS, pH 7.4. Endotoxin: Less than 1EU/mg of rMuIL-6 as determined by LAL method.

UPC:

51204100

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

RC232-17.SIZE.1mg