IPI-3063 (C007B-196790)

InformationIPI-3063 is a potent and selectivep110δinhibitor with biochemical IC50 of 2.5 ± 1.2 nM and IC50 values for the other class I PI3K isoforms (p110α, p110β, p110γ) are at least 400-fold higher.Targetsp110δ (Cell-free assay) 2.5 nMIn vitroIPI-3063 is a p110δ selective compound with an IC50/u2009=/u20090.1/u2009nM in p110δ-specific cell-based assays and cellular IC50 values for the other class I PI3K isoforms are at least 1,000-fold higher. IPI-3063 potently reduces mouse B cell proliferation, survival, and plasmablast differentiation.In vivoIPI-3063 has good pharmacokinetics in mice.Cell Research(from reference)Cell lines：purified mouse B cells Concentrations：0.01, 0.1, 1, 10, 30, 100/u2009nM Incubation Time：48 h. Specification: 10mM in DMSO Molecular Formula: C25H25N7O2 Molecular Weight: 455.51 PubChem CID: 71276090 Isomeric SMILES: C[C@@H](C1=CC2=C(C(=CC=C2)C3=CN(C(=O)C=C3)C)C(=O)N1C(C)C)NC4=NC=NC(=C4C#N)N

UPC:

51111746

Condition:

New

Weight:

0.85 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

I421572-1ml

CAS:

1425043-73-7

Product Size:

1ml