Istaroxime hydrochloride (C007B-362570)

Istaroxime hydrochloride is a Na + /K + -ATPase inhibitor ( IC 50 =0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ( SERCA 2 ) activator.In VitroIstaroxime hydrochloride acting as a positive inotropic compound through the inhibition of the Na + ,K + -ATPase. Istaroxime (PST2744) inhibits the Na + /K + -ATPase activity from dog kidney with an IC 50 value of 0.43 ± 0.15 μM. Inhibition of Na + /K + -ATPase activity in preparations from guinea pig kidney yielded potencies of 8.5 μM for PST2744. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoIstaroxime (PST2744) induces a progressive increase in +dP/dt max throughout the infusion that reaches 80% (ED 80 ) at the cumulative dose of 1.89±0.37 mg/kg and a peak of 140±3.5% at the dose (ED max ) of 4.88±0.6 mg/kg. MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:IC50: 0.11 μM (Na + ,K + -ATPase). Specification: 10mM in DMSO Molecular Formula: C21H33ClN2O3 Molecular Weight: 396.95

UPC:

51172339

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

I655614-1ml

CAS:

374559-48-5

Product Size:

1ml