ISX-9

ISX-9 (Isoxazole 9) (GMP) is a GMP grade ISX-9. GMP grade small molecules can be used as auxiliary reagents in cell therapy. ISX-9 is a small molecule with antioxidant, pro survival, and regenerative properties.Biological activity:ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca2+ influx through both voltage-gated Ca2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs). In Vitro: ISX-9 promotes neurogenesis in vivo, enhancing the proliferation and differentiation of hippocampal subgranular zone (SGZ) neuroblasts, and the dendritic arborization of adult-generated dentate gyrus neurons. At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression.Molecular exploration of ISX-9-induced regulation of neurogenesis (via FACS and microarray of SGZ stem and progenitor cells) suggested the involvement of the myocyte-enhancer family of proteins (Mef2). In Vivo: ISX-9 (20 mg/kg; for 12 days; mice) treatment improves hippocampal function. ISX-9 enhances spatial memory ability in the Morris water maze test. ISX-9 enhances hippocampal neurogenesis and memory in vivo, and its effects are reliant on Mef2.

Specification: GMP

Molecular Formula: C11H10N2O2S

Molecular Weight: 234.27

PubChem CID: 19582717

Isomeric SMILES: C1CC1NC(=O)C2=NOC(=C2)C3=CC=CS3

Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/I1372002-GMP-SCI_13ace344efa190ab2d30bba19ee2f69d.pdf

UPC:

51292803

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

I1372002-GMP-1mg

Product Size:

1mg

CAS:

832115-62-5