Kazusamycin B

Kazusamycin B is a minor component of the leptomycin complex produced from the fermentation of the broth of a|Streptomyces sp.|. The compound is a hydroxylated analogue of Leptomycin A , a nuclear export inhibitor, and highly lipophillic.|In vitro|antitumor activity of Kazusamycin B on tumors L1210, P388/S, B16, HeLa S3, L5178Y-ML or L929 was ascertained to have an IC|50|of 1.8, 2.0, 0.7, 1.8, 10.0 and l.0 ng/ml when cultured in the presence of Kazusamycin B for 72 hours. The compound has also displayed broad antitumor activity in mice with effectiveness being more dependent on dosing regimen than dosing concentration both|in vivo|and|in vitro|. Kazusamycin B also possesses antibacterial and antifungal activity. Specification: >95% Molecular Formula: C32H46O7 Molecular Weight: 542.7 PubChem CID: 6436293 Isomeric SMILES: CC1C=CC(=O)OC1/C=C/C(=C/C(C)C/C=C/C(=C/C(CO)C(=O)C(C)C(C(C)C/C(=C/C(=O)O)/C)O)/C)/C Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/K329568-SCI_996df9d007d1ddbd5105f22e6e4f8350.pdf

UPC:

51111733

Condition:

New

Weight:

0.96 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

K329568-100μg

CAS:

107140-30-7

Product Size:

100μg

Precautionary Statement Codes:

P264