KHS101 hydrochloride (C007B-199238)

InformationKHS101 hydrochloride KHS101 is a small-molecule inhibitor of TACC3 , which is a key component of centrosome-microtubule dynamic networks.TargetsTACC3In vitroIn two intracranial patient-derived xenograft tumor models in mice (glioblastoma multiforme and neural progenitor cell models), systemic administration of KHS101 reduced tumor growth and increased survival without discernible side effects. KHS101 crosses the blood-brain barrier (BBB) and selectively induces neuronal differentiation of hippocampal neural progenitor cells in vitro and in vivo. KHS101 treatment increases survival of glioblastoma multiforme xenograft tumor-bearing mice.In vivoIn two intracranial patient-derived xenograft tumor models in mice (glioblastoma multiforme and neural progenitor cell models), systemic administration of KHS101 reduced tumor growth and increased survival without discernible side effects. KHS101 crosses the blood-brain barrier (BBB) and selectively induces neuronal differentiation of hippocampal neural progenitor cells in vitro and in vivo. KHS101 treatment increases survival of glioblastoma multiforme xenograft tumor-bearing mice.Cell Research(from reference)Cell lines：GBM cells Concentrations：7.5 μM Incubation Time：12 h. Specification: 0.99 Molecular Formula: C18H22ClN5S Molecular Weight: 339.463646 PubChem CID: 90488983 Isomeric SMILES: CC(C)CNC1=NC(=NC=C1)NCC2=CSC(=N2)C3=CC=CC=C3.Cl Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/K413367-SCI_6835fac3fbe45d75598e7fddb141c508.pdf

UPC:

51142560

Condition:

New

Weight:

0.96 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

K413367-5mg

CAS:

1784282-12-7

Product Size:

5mg