General description
An orally bioavailable in-vivo prodrug of KMO Inhibitor I, Ro 61-8048 (Cat. No. 420360) that is shown to be metabolically unstable and slowly release Ro 61-8048 in blood and act as a neuroprotectant. Blocks KMO peripherally (IC50 = 4 µM) and sustainingly elevates kynurenic acid (KYNA) brain levels, an antagonist of excitatory amino acid receptors. Shown to prevent synaptic loss and behavioral deficits in AD and HD mouse model and increase the survival.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Campesan, S., et al. 2011. Chem. Biol.21, 961.
Zwilling, D., et al. 2011. Cell145, 863.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 518.61. Empirical Formula: C23H26N4O6S2. Quality Level: 100. Assay: ≥. 97% (HPLC). form: powder. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, protect from light. color: yellow. solubility: DMSO: 5 . mg/mL. shipped in: wet ice. storage temp.: 2-8°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 51282131
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 420361-10MG