KPNA2 Mouse mAb (C008B-270228)

Mouse anti Human KPNA2 Antibody, Monoclonal (C8), could be used for WB, IHC and so on.Application:WB: 0.01-3µg/mLIHC : 5-20µg/mL Protein FunctionFunctions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

mAb(C8); Mouse anti Human KPNA2 Antibody; WB, IHC; Unconjugated

Specifications & Purity: Mouse anti Human KPNA2 Antibody, Monoclonal (C8), could be used for WB, IHC and so on.Application:WB: 0.01-3µg/mLIHC : 5-20µg/mL Protein FunctionFunctions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Grade: Carrier Free;Recombinant;ExactAb™;Azide Free;Validated;High Performance;PBS Only

Storage Temperature: Store at -20°C;Avoid repeated freezing and thawing

Shipped in: Ice chest + Ice pads

UPC:

41106514

Weight:

1.09 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

Ab337069-50μg

Country of Origin:

China

Product Size:

50μg

Harmonized Tariff Code:

2931.90.90