Life Science

A1 is a receptor for adenosine. It is demonstrated that the A1 receptor is ubiquitous throughout the entire body.

The adenosine receptors ADORA2A is Gs-coupled GPCRs expressed in the thymus gland, heart, lung, kedney, brain, platelets, spleen and leukocytes. ADORA2A down-regulates chemokine receptor function and inhibits platelet aggregation.

The adenosine receptors ADORA2B is G_s and G_q/11-coupled GPCR expressed in the Large intestine, cecum, urinary bladder. ADORA2B receptor mediates relaxation to adenosine in human small coronary arteries which is independent of

Extracellular adenosine mediates a multitude of biological effects, including wakefulness, antiarrythmia, bronchoconstriction and response to ischemia and oxidative stress. A family of four G-protein coupled adrenoceptors, A1, A2A, A2B and A3, is

The a1-adrenergic receptor (AR) family consists of three closely related gene products (a_1A, a_1B, and a_1D) that mediate the actions of norepinephrine (NE) and epinephrine in sympathetically innervated tissues and

The a₁-adrenergic receptor (AR) family consists of three closely related gene products (a_1A, a_1B, and a_1D). They mediate the actions of norepinephrine (NE) and epinephrine in sympathetically innervated

The a1-adrenergic receptor (AR) family consists of three closely related gene products (a1A, a1B, and a1D). They mediate the actions of norepinephrine (NE) and epinephrine in sympathetically innervated tissues and brain.

The adrenoceptors ADRA2A is expressed in the brain, spleen, kidney, aorta, lung, skeletal muscle, heart and liver. ADRA2A -adrenoceptor knockout mice exhibit disruption of presynaptic inhibition of noradrenaline release at high stimulation

Adrenoceptors are 7-transmembrane receptors which mediate the central and peripheral actions of the neurotransmitter, noradrenaline (norepinephrine), and the hormone and neurotransmitter, adrenaline (epinephrine). Based on both pharmacological and

The adrenoceptors ADRA2C is expressed in the brain, kidney, aorta, lung, skeletal muscle, heart and spleen. ADRA2C knockout mice exhibited disrupts presynaptic inhibition of noradrenaline release at low stimulation frequencies.

The ß-adrenergic receptors are linked to G proteins. The ß-receptor has three known subtypes.

The apelin receptor AGTRL1 is G_i/G_o-coupled GPCRs expressed in the heart, coronary artery, aorta, internal mammary artery, pulmonary artery and saphenous vein, it also expressed in lung, kidney and adrenal gland. In AGTRL1