Biologically Active Small Molecules

3,4-Dihydroxyphenyl ethanol is a phenolic component of olive oil that inhibits both 12- and 5-LO. The IC₅₀ values for the inhibition of rat platelet 12-LO and rat neutrophil 5-LO are 4.

3,4-Dihydroxyphenyl ethanol is a phenolic component of olive oil that inhibits both 12- and 5-LO. The IC₅₀ values for the inhibition of rat platelet 12-LO and rat neutrophil 5-LO are 4.

3,4-Dihydroxyphenyl ethanol is a phenolic component of olive oil that inhibits both 12- and 5-LO. The IC₅₀ values for the inhibition of rat platelet 12-LO and rat neutrophil 5-LO are 4.

3,4-Dihydroxyphenyl ethanol is a phenolic component of olive oil that inhibits both 12- and 5-LO. The IC₅₀ values for the inhibition of rat platelet 12-LO and rat neutrophil 5-LO are 4.

A selective nonphosphoinositide inhibitor with favorable solubility in vivo that specifically disrupts PIP3/Akt PH domain binding (IC50 = 27 &muM) suppresses PI3K-PDK1-Akt-dependent phosphorylation, which reduces cell viability and induces

A selective nonphosphoinositide inhibitor with favorable solubility in vivo that specifically disrupts PIP3/Akt PH domain binding (IC50 = 27 &muM) suppresses PI3K-PDK1-Akt-dependent phosphorylation, which reduces cell viability and induces

A selective nonphosphoinositide inhibitor with favorable solubility in vivo that specifically disrupts PIP3/Akt PH domain binding (IC50 = 27 &muM) suppresses PI3K-PDK1-Akt-dependent phosphorylation, which reduces cell viability and induces

A selective nonphosphoinositide inhibitor with favorable solubility in vivo that specifically disrupts PIP3/Akt PH domain binding (IC50 = 27 &muM) suppresses PI3K-PDK1-Akt-dependent phosphorylation, which reduces cell viability and induces

A fluorescent probe for monitoring intracellular pH by flow cytometry in living cells.

A fluorescent probe for monitoring intracellular pH by flow cytometry in living cells.

A fluorescent probe for monitoring intracellular pH by flow cytometry in living cells.

A ROCK-I inhibitor (IC₅₀ = 25 &microM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay also inhibits ROCK-II and PRK2 with similar potency, while