Biologically Active Small Molecules

An agonist of GPR81 (EC₅₀ = 16 &microM) that is inactive against the related GPR109a (HCAR2) receptor stimulates lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks blocks basal ghrelin secretion by

Strongly inhibits lymphocyte-mediated cytolysis with low cytotoxicity when applied at 100 &muM can also be used to evaluate the role of the adenine N3 nitrogen in DNA structure and function.

Strongly inhibits lymphocyte-mediated cytolysis with low cytotoxicity when applied at 100 &muM can also be used to evaluate the role of the adenine N3 nitrogen in DNA structure and function.

Strongly inhibits lymphocyte-mediated cytolysis with low cytotoxicity when applied at 100 &muM can also be used to evaluate the role of the adenine N3 nitrogen in DNA structure and function.

Strongly inhibits lymphocyte-mediated cytolysis with low cytotoxicity when applied at 100 &muM can also be used to evaluate the role of the adenine N3 nitrogen in DNA structure and function.

An inhibitor of SAH hydrolase (Ki = 3.9 &muM) has anti-inflammatory, anti-viral, and anti-bacterial activities.

An inhibitor of SAH hydrolase (Ki = 3.9 &muM) has anti-inflammatory, anti-viral, and anti-bacterial activities.

An inhibitor of SAH hydrolase (Ki = 3.9 &muM) has anti-inflammatory, anti-viral, and anti-bacterial activities.

An analog of 3-deazaadenosine, an inhibitor of SAH hydrolase depletes EZH2 levels and inhibits trimethylation of lysine 27 on histone H3 in primary human AML cells in a dose-dependent manner (0.2-1 &muM) acts synergistically with the pan-HDAC

An analog of 3-deazaadenosine, an inhibitor of SAH hydrolase depletes EZH2 levels and inhibits trimethylation of lysine 27 on histone H3 in primary human AML cells in a dose-dependent manner (0.2-1 &muM) acts synergistically with the pan-HDAC

An analog of 3-deazaadenosine, an inhibitor of SAH hydrolase depletes EZH2 levels and inhibits trimethylation of lysine 27 on histone H3 in primary human AML cells in a dose-dependent manner (0.2-1 &muM) acts synergistically with the pan-HDAC

An inhibitor of SAH hydrolase depletes EZH2 levels and inhibits trimethylation of lysine 27 on histone H3 in acute myeloid leukemia cells in a dose-dependent manner (0.2-1 &muM) increases expression of the cell-cycle regulators p21, p27, and