Biologically Active Small Molecules

A potent inhibitor of the STAT3/JAK signaling pathway suppresses levels of tyrosine phosphorylated STAT3, STAT3 DNA binding and STAT3-mediated gene transcription suppresses tumor growth in vivo.

A potent inhibitor of the STAT3/JAK signaling pathway suppresses levels of tyrosine phosphorylated STAT3, STAT3 DNA binding and STAT3-mediated gene transcription suppresses tumor growth in vivo.

Epoxyeicosatrienoic acid (EpETrE EET) metabolites of arachidonic acid such as 11(12)-EET and 14(15)-EET have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the

Epoxyeicosatrienoic acid (EpETrE EET) metabolites of arachidonic acid such as 11(12)-EET and 14(15)-EET have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the

Epoxyeicosatrienoic acid (EpETrE EET) metabolites of arachidonic acid such as 11(12)-EET and 14(15)-EET have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the

Epoxyeicosatrienoic acid (EpETrE EET) metabolites of arachidonic acid such as 11(12)-EET and 14(15)-EET have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the

A multi-target inhibitor that potently blocks EGFR and HER2 (IC₅₀s = 2.4 and 16.

A multi-target inhibitor that potently blocks EGFR and HER2 (IC₅₀s = 2.4 and 16.

A multi-target inhibitor that potently blocks EGFR and HER2 (IC₅₀s = 2.4 and 16.

A multi-target inhibitor that potently blocks EGFR and HER2 (IC₅₀s = 2.4 and 16.

A potent inhibitor of hedgehog-induced cellular activity (IC₅₀ = 100-200 nM) binds directly with the pathway activator Smo (Ki = 44 nM) blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of

A potent inhibitor of hedgehog-induced cellular activity (IC₅₀ = 100-200 nM) binds directly with the pathway activator Smo (Ki = 44 nM) blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of