Reagents

The nonapeptide 149,YFPGQFAFS157 (chemerin-9), corresponding to the C terminus of processed chemerin, retained most of the activity of the full-size protein, with regard to agonism toward the chemerinR.the natural ligand of ChemR23 (chemerinR).

Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein that in humans is encoded by the PDCD1 gene.PD-1, functioning as an immune checkpoint, plays an important role in down regulating the immune

The 5-Hydroxytryptamine receptor 1A (5-HT1A) is G_i-coupled GPCRs expressed in the cerebral cortex, hippocampus, septum, amygdala, and raphe nucelus, with lesser amounts in the basal ganglia and thalamus. Many functions of the central

5-Hydroxytryptamine (5-HT, also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and

5-Hydroxytryptamine (5-HT, also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and

5-Hydroxytryptamine (5-HT, also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and

5-HT4 is a human serotonin G protein-coupled receptor. Several studies suggested that intact 5-HT systems are important determinants of sensitivity and/or tolerance to ethanol-induce ataxia hypothermia.

A1 is a receptor for adenosine. It is demonstrated that the A1 receptor is ubiquitous throughout the entire body.

The adenosine receptors ADORA2A is Gs-coupled GPCRs expressed in the thymus gland, heart, lung, kedney, brain, platelets, spleen and leukocytes. ADORA2A down-regulates chemokine receptor function and inhibits platelet aggregation.

The adenosine receptors ADORA2B is G_s and G_q/11-coupled GPCR expressed in the Large intestine, cecum, urinary bladder. ADORA2B receptor mediates relaxation to adenosine in human small coronary arteries which is independent of

Extracellular adenosine mediates a multitude of biological effects, including wakefulness, antiarrythmia, bronchoconstriction and response to ischemia and oxidative stress. A family of four G-protein coupled adrenoceptors, A1, A2A, A2B and A3, is

The a1-adrenergic receptor (AR) family consists of three closely related gene products (a_1A, a_1B, and a_1D) that mediate the actions of norepinephrine (NE) and epinephrine in sympathetically innervated tissues and