Lasmiditan succinate

Lasmiditan succinate (COL-144, LY573144) is a novel, centrally acting, highly selective5-HT(1F) receptoragonist (Ki=2.21 nM) without vasoconstrictor activity.Targets5-HT(1F) (Cell-free assay) 2.21 nM(Ki)In vitroLasmiditan shows higher selectivity for the 5-HT(1F) receptor relative to other 5-HT(1) receptor subtypes than the first generation 5-HT(1F) receptor agonist LY334370.In vivoLasmiditan is orally active in two in vivo models of migraine that involve electrical stimulation of the trigeminal ganglion. After oral administration, lasmiditan potently decreases dural plasma protein extravasation and the number of c-fos positive cells in the trigeminal nucleus caudalis at a dose of 3 mg/kg.

5-HT1 Selective Inhibitors | Agonists | Antagonists | Modulators

Specifications & Purity: Lasmiditan succinate (COL-144, LY573144) is a novel, centrally acting, highly selective5-HT(1F) receptoragonist (Ki=2.21 nM) without vasoconstrictor activity.Targets5-HT(1F) (Cell-free assay) 2.21 nM(Ki)In vitroLasmiditan shows higher selectivity for the 5-HT(1F) receptor relative to other 5-HT(1) receptor subtypes than the first generation 5-HT(1F) receptor agonist LY334370.In vivoLasmiditan is orally active in two in vivo models of migraine that involve electrical stimulation of the trigeminal ganglion. After oral administration, lasmiditan potently decreases dural plasma protein extravasation and the number of c-fos positive cells in the trigeminal nucleus caudalis at a dose of 3 mg/kg.

Molecular Formula: C42H42F6N6O8

Molecular Weight: 872.81

EC Number: 815-300-4

PubChem CID: 46927777

Isomeric SMILES: CN1CCC(CC1)C(=O)C2=NC(=CC=C2)NC(=O)C3=C(C=C(C=C3F)F)F.CN1CCC(CC1)C(=O)C2=NC(=CC=C2)NC(=O)C3=C(C=C(C=C3F)F)F.C(CC(=O)O)C(=O)O

Storage Temperature: Store at -20°C

Shipped in: Ice chest + Ice pads

More Information: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/L413481-SCI_03973173934ae09bec5764ee2e631243.pdf

UPC:

51291711

Weight:

1.06 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

L413481-1mg

Country of Origin:

China

CAS:

439239-92-6

Product Size:

1mg

Harmonized Tariff Code:

2931.90.90

Health Hazards:

Corrosive

Hazard Statement Codes:

H302;H318;H336;H361

Precautionary Statement Codes:

P261;P264;P270;P271;P280;P330;P304+P340;P405;P403+P233;P501;P203;P264+P265;P301+P317;P305+P354+P338;P318;P317;P319