Activin and Inhibin

IDH1 Inhibitor 1 is a potent, orally bioavailable, brain-penetrant and selective mutant IDH1 inhibitor with IC 50 s of 0.021 μM, 0.045 μM, and 2.52 μM for IDH1 R132H , IDH1 R132C , and IDH1 WT , respectively Anticancer activityIn VitroIDH1

IDH1 Inhibitor 2 (compound 13) is a potent wild-type IDH1 inhibitor via a direct covalent modification of His315, with an IC 50 of 110 nMForm:SolidIC50&amp: Target:IDH1.

IDH1 Inhibitor 7 (Compound 88) is an IDH1 inhibitor with an IC 50 of less than 100 nMForm:SolidIC50&amp: Target:IDH1 &lt:100 nM (IC 50 ).

IDH1 Inhibitor 7 (Compound 88) is an IDH1 inhibitor with an IC 50 of less than 100 nMForm:SolidIC50&amp: Target:IDH1 &lt:100 nM (IC 50 ).

IDH1 Inhibitor 7 (Compound 88) is an IDH1 inhibitor with an IC 50 of less than 100 nMForm:SolidIC50&amp: Target:IDH1 &lt:100 nM (IC 50 ).

IDH1 Inhibitor 7-d 2 is the deuterium labeled IDH1 Inhibitor 7 ( HY-150238 ). IDH1 Inhibitor 7 is an IDH1 inhibitor with an IC 50 of less than 100 nM.In VitroStable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into

IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1) . IDH889 has potent selectivity for IDH1 R132* mutations, with IC 50 s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1 R132H ,

IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1) . IDH889 has potent selectivity for IDH1 R132* mutations, with IC 50 s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1 R132H ,

IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1) . IDH889 has potent selectivity for IDH1 R132* mutations, with IC 50 s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1 R132H ,

IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1) . IDH889 has potent selectivity for IDH1 R132* mutations, with IC 50 s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1 R132H ,

IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1) . IDH889 has potent selectivity for IDH1 R132* mutations, with IC 50 s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1 R132H ,

IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1) . IDH889 has potent selectivity for IDH1 R132* mutations, with IC 50 s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1 R132H ,