Ligands of Immunopharmacology

diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist.In VitroThe author developed a linking strategy to synergize the effect of two symmetry-related amidobenzimidazole (ABZI)-based compounds to create linked

diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist.In VitroThe author developed a linking strategy to synergize the effect of two symmetry-related amidobenzimidazole (ABZI)-based compounds to create linked

Diclofenac-d 4 (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor , with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and

Diprovocim-X (compound 35) is a potent TLR1/TLR2 (toll-like receptor 1/2) agonist, with EC 50 values of 0.14 and 0.75 nM for hTLR1/TLR2 and mTLR1/TLR2, respectively. Diprovocim-X is a potent adjuvant in vivo in mice, and serves to stimulate the

DOCK2-IN-1 (compound 3), a CPYPP ( HY-110100 ) analogue, is an inhibitor of DOCK2 as well ( IC 50 =19.1 μM). DOCK2-IN-1 binds to DOCK2 DHR-2 domain in a reversible manner to inhibits its catalytic activity. DOCK2-IN-1 blocks the activation of both

DOCK2-IN-1 (compound 3), a CPYPP ( HY-110100 ) analogue, is an inhibitor of DOCK2 as well ( IC 50 =19.1 μM). DOCK2-IN-1 binds to DOCK2 DHR-2 domain in a reversible manner to inhibits its catalytic activity. DOCK2-IN-1 blocks the activation of both

E7766 diammonium salt is a macrocycle-bridged STING agonist with a K d of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities.In VitroE7766 diammonium salt inhibits four human STING variants, human wild-type, HAQ, AQ and

E7766 diammonium salt is a macrocycle-bridged STING agonist with a K d of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities.In VitroE7766 diammonium salt inhibits four human STING variants, human wild-type, HAQ, AQ and

E7766 diammonium salt is a macrocycle-bridged STING agonist with a K d of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities.In VitroE7766 diammonium salt inhibits four human STING variants, human wild-type, HAQ, AQ and

Edecesertib (GS-5718) is a selective, potent, orally active IRAK-4 inhibitor. Edecesertib has anti-inflammatory activity. Edecesertib can be used for rheumatoid arthritis (RA) and lupus erythematosus (LE) research.Form:Solid

Edecesertib (GS-5718) is a selective, potent, orally active IRAK-4 inhibitor. Edecesertib has anti-inflammatory activity. Edecesertib can be used for rheumatoid arthritis (RA) and lupus erythematosus (LE) research.Form:Solid

Emlenoflast (MCC7840) sodium, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome , with an IC 50 of &lt100 nM. Emlenoflast sodium can be used for the research of inflammatory diseasesIn VitroEmlenoflast, a MCC950 analogue,