Lirimilast (C007B-581840)

Lirimilast (BAY 19-8004) is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC 50 value of 49 nM. Lirimilast can be used for the treatment of asthma or chronic obstructive pulmonary disease (COPD). Lirimilast has potently anti-inflammatory propertiesIn VitroIn PDE4 assays Lirimilast (BAY 19-8004) is reported to be 5-fold more potent than Cilomilast and equipotent with CDP-840 using freshly prepared PDE4 from human PMNL. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoSince Lirimilast (BAY 19-8004) is orally active in the guinea-pig at 3 mg/kg and, more critically, in primates at 0.1 mg/kg/day it appears to have a good therapeutic ratio. In addition Lirimilast is found to be 3-fold more potent than Cilomilast when compared in a rat model of lung neutrophilic inflammation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:PDE4 42 nM (IC 50 )

Specifictaions: Moligand™, ≥98%

MDL Number: C17H12Cl2N2O6S

Molecular Formula: 443.26

PubChem CID: 6433118

Isomeric SMILES: CS(=O)(=O)OC1=CC2=C(C=C1)C(=C(O2)C(=O)C3=C(C=C(C=C3)Cl)Cl)NC(=O)N

UPC:

51431703

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

L649837-50mg

CAS:

329306-27-6

Product Size:

50mg