Litronesib (C007B-364786)

Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activityIn VitroLitronesib (LY2523355) is a selective Eg5 inhibitor. Litronesib (25 nM) induces cancer cells to death during mitotic arrest, and this needs sustained activation of spindle-assembly checkpoint (SAC). MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoLitronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) shows antitumor activity in a dose-dependently, and causes a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Eg5. Specification: ≥97% Molecular Formula: C23H37N5O4S2 Molecular Weight: 511.7 PubChem CID: 25167017 Isomeric SMILES: CCNCCS(=O)(=O)NC[C@@]1(N(N=C(S1)NC(=O)C(C)(C)C)C(=O)C(C)(C)C)C2=CC=CC=C2

UPC:

12352200

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

L650229-2mg

CAS:

910634-41-2

Product Size:

2mg