LTV-1 (C008B-275003)

LTV-1 is a potent lymphoid tyrosine phosphatase ( LYP ) inhibitor in T cells with an IC 50 of 508 nM. LTV-1 has the potential for autoimmunity treatmentIn VitroLTV-1 (1.25-40 μM) has no notable effect on cell viability (metabolic rate assay), even at the highest concentration tested (40 μM). Thus, LTV-1 is not cytotoxic in HeLa cells, Jurkat TAg T cells and peripheral blood mononuclear cells (PBMC). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HeLa cells, Jurkat TAg T cells, and PBMC Concentration: 1.25, 2.5, 5.0, 10, 20 , and 40 μM Incubation Time: 48 hours Result: Had no notable effect on cell viability (metabolic rate assay), even at the highest concentration tested (40 μM).Form:SolidIC50& Target:IC50: 508 nM (LYP, in T cells)

Specifications & Purity: LTV-1 is a potent lymphoid tyrosine phosphatase ( LYP ) inhibitor in T cells with an IC 50 of 508 nM. LTV-1 has the potential for autoimmunity treatmentIn VitroLTV-1 (1.25-40 μM) has no notable effect on cell viability (metabolic rate assay), even at the highest concentration tested (40 μM). Thus, LTV-1 is not cytotoxic in HeLa cells, Jurkat TAg T cells and peripheral blood mononuclear cells (PBMC). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HeLa cells, Jurkat TAg T cells, and PBMC Concentration: 1.25, 2.5, 5.0, 10, 20 , and 40 μM Incubation Time: 48 hours Result: Had no notable effect on cell viability (metabolic rate assay), even at the highest concentration tested (40 μM).Form:SolidIC50& Target:IC50: 508 nM (LYP, in T cells)

Grade: Moligand™

Molecular Formula: C26H20N2O5S

Molecular Weight: 472.51

EC Number: 803-585-8

PubChem CID: 1920999

Isomeric SMILES: CC1=CC=CC=C1N2C(=O)/C(=C/C3=CC=C(C=C3)OCC4=CC(=CC=C4)C(=O)O)/C(=O)NC2=S

Storage Temperature: Store at -20°C

Shipped in: Ice chest + Ice pads

UPC:

51342707

Weight:

1.09 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

L651598-100mg

Country of Origin:

China

CAS:

347379-29-7

Product Size:

100mg

Harmonized Tariff Code:

2931.90.90