MC1742 (C005B-309981)

Biochem/physiol Actions

MC1742 is a uracil-based hydroxyamide (UBHA) that acts as a subtype-selective histone deacetylases (HDACs) inhibitor (IC₅₀: class I HDAC1/2/3/8 = 100/110/20/610 nM, class IIB HDAC6/10 = 7/40 nM, class IV HDAC11 = 100 nM, class IIA HDAC4/5/7/9 >50 μM). MC1742 exerts greater antiproliferation potency than SAHA in sarcoma cancer stem cell (CSC) cultures (MC1742/SAHA IC₅₀ in μM = 0.25/1/RD, 1.12/1.13//MG-63, 1.4/3.92/SK-ES-1 post 72-hr treatment) and effectively reactivates HIV from latency (EC₅₀ = 350 nM; JLAT 10.6 cells) by upregulating histone acetylation at the HIV promoter without activating T cells.

UPC:

51303206

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

25

Unit of Measurement:

MG

MPN:

SML2862-25MG

CAS:

1776116-74-5