Improsulfan

Biochem/physiol Actions GSK&#8242:481 is a highly potent receptor interacting protein 1 kinase (RIP1, RIPK1) inhibitor (human/monkey RIP1 IC 50 &nbsp:= 1.6/2.

Biochem/physiol Actions GSK&#8242:481 is a highly potent receptor interacting protein 1 kinase (RIP1, RIPK1) inhibitor (human/monkey RIP1 IC 50 &nbsp:= 1.6/2.

A cell-permeable, potent, and selective blocker of necroptosis (EC 50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-&#945), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection

Product IntroductionNecrostatin-5 is an inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase. Necroptosis is defined as alternative active cell death pathway: Death-Domain Receptor (DRs, e.g. Fas/TNFR)

Product IntroductionNecrostatin-5 is an inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase. Necroptosis is defined as alternative active cell death pathway: Death-Domain Receptor (DRs, e.g. Fas/TNFR)

Product IntroductionNecrostatin-5 is an inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase. Necroptosis is defined as alternative active cell death pathway: Death-Domain Receptor (DRs, e.g. Fas/TNFR)

Product IntroductionNecrostatin-5 is an inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase. Necroptosis is defined as alternative active cell death pathway: Death-Domain Receptor (DRs, e.g. Fas/TNFR)

A selective allosteric inhibitor of RIP1 kinase that prevents the death of TNF-&alpha-treated FADD-deficient Jurkat cells with an EC50 value of 240 nM.