Necrostatin-5 (C007B-246053)

Product IntroductionNecrostatin-5 is an inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase. Necroptosis is defined as alternative active cell death pathway: Death-Domain Receptor (DRs, e.g. Fas/TNFR) mediated and caspase-inhibitor insensitive with specific morphology (nuclear condensation, organelle swelling, loss of plasma membrane integrity). The necrostatins have been discovered to inhibit this pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved: T-loop dependent inhibition by necrostatin-1 partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5, since necrostatin-5 is a potent inhibitor of immunnoprecipitated RIP1, but does not inhibit recombinant RIP1.ApplicationNecrostatin-5 is an inhibitor of necroptosis by indirect inhibition of RIP1 kinase. Specification: ≥98% Molecular Formula: C19H17N3O2S2 Molecular Weight: 383.49 PubChem CID: 1913406 Isomeric SMILES: COC1=CC=C(C=C1)N2C(=O)C3=C(N=C2SCC#N)SC4=C3CCCC4 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/N274792-SCI_4fd8ffaf2f04391f4d0dc2c5b4370e75.pdf

UPC:

51112302

Condition:

New

Weight:

0.96 Ounces

HazmatClass:

No;ManufacturerName=Aladdin Scientific"

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

N274792-250mg

CAS:

337349-54-9

Product Size:

250mg

Hazard Statement Codes:

H319:H413

Precautionary Statement Codes:

P264:P273:P280:P305+P351+P338:P501

Controlled Substances and Cyanide:

Yes